1. What is Inositol?

This chemical is carbocyclic sugar. It is found in abundant quantities in the mammalian brain and other tissues. It serves an important part in a cell signaling pathway in response to several other chemicals such as hormones, growth factors, and neurotransmitters. 

Inositol is manufactured with help of glucose and is often used as a dietary supplement for women suffering from polycystic ovary syndrome or PCOS. It was first isolated by Scherer and called “inosite” owing to its sweet taste. 

• Definition

Inositol is a naturally occurring sugar found in cell membrane phospholipids and plasma lipoproteins. It is a collection of nine different isomers but the name collectively refers to the most common type called Myo-inositol. 

• Chemical& Physical features
  

• IUPAC name: cyclohexane-1,2,3,4,5,6-hexol

• Synonyms: Myo-inositol, Scyllo-inositol, Muco-Inositol, epi-Inositol

• CAS: 87-89-8

• Molecular formula: C6H12O6

• Molecular weight: 180.16

• Form: crystalline powder

• Color: white

• Solubility: soluble in water, slightly soluble in ethanol, alcohol, DMSO, and insoluble in ether.

• Brand names
  

• Alnamet MYO 

• Fersitol

• Fertisop

• Hexin

• Inositol Pharma Arte

• Lysine-Vitamin B12 - 999

• Metiocolin B12 

• Neo-Cholal

• Nicosit

2. Inositol forms and specifications

Inositol is available in different specifications and forms. Depending on the use, these different forms can be used. Some of these are:

• Inositol powder 98%
  

Inositol powder which comes in 98% purity concentration is usually used as raw material to manufacture inositol dietary supplements and medications. It is a white crystalline powder that is odorless and sweet in taste. This form usually refers to Myo-inositol. 

• D-chiro inositol powder
  

D-chiro inositol powder is another isomer of inositol that is also available in powder form. It is crystalline and white. It is widely used to manufacture drugs for conditions like PCOS, gestational diabetes, and metabolic syndrome. 

• Inositol hexanicotinate powder

Inositol hexanicotinate powder is also a stereoisomer of inositol. It is available in powder form to manufacture other drugs as well. It is primarily used to make drugs that can be used to help with endothelium-dependent vasodilatation. Inositol hexanicotinate powder improves blood flow by widening the blood vessels, so can be used for hypertension drugs.

3. Myo-Inositol VS d-chiro inositol

The basic difference between these two is that they are different isomers of the same compound. These two isomers are involved in different bodily functions so their use is also diverse. Myo-inositol is usually involved in the transporters' activation and how the body uses glucose. On the other hand, d-chiro inositol is involved primarily in glycogen synthesis and storage in human and mammalian bodies. 

4. Mechanism of Action of Inositol

There are different mechanisms of action involved when it comes to the use of inositol by the body. In brain disorders, it is hypothesized that it may be involved in neurotransmitter synthesis and may be a precursor to the phosphatidylinositol cycle. For PCOS, it helps by acting as a direct messenger of insulin signaling and by improving glucose tissue uptake. In cancer, inositol may help by increasing lower-phosphate inositol phosphates which can affect the growth and differentiation of malignant cells. 

5. Inositol Manufacturing Process

Inositol is manufactured by using glucose. There are two steps involved. First, glucose or glucose 6-phosphate (G6P) is isomerized by an inositol-3-phosphate synthase enzyme. This leads to the production of myo-inositol 1-phosphate. Myo-inositol 1-phosphate is then dephosphorylated using an inositol monophosphatase enzyme. At the end of this process, free Myo-inositol is formed. 

6. Inositol Benefits

This chemical has widespread use for the treatment of several health issues. It is essentially a lipotropic agent. Here is how inositol and its isomers are primarily used. 

• Inositol weight loss

Inositol has been seen to induce weight loss in some women who may be suffering from PCOS.

• Inositol for PCOS

In PCOS, many women suffer from inulin insensitivity. Inositol has been observed to improve insulin sensitivity in women suffering from PCOS. 

• Inositol anxiety

Inositol can alleviate anxiety by improving the function of serotonin which is a neurotransmitter found in the brain. 

• Myo-inositol fertility

Women suffering from PCOS can have reduced fertility. Inositol can improve the function of ovaries and may increase fertility in such women according to some studies. 

7. Inositol Side Effects

Like all drugs and chemicals, inositol can have some side effects on some people. These side effects can be:

• Stomach pain

• Headaches

• Dizziness

• Nausea

• Fatigue

8. Inositol Market Size & Trends

Inositol's market share is expected to grow in the coming years. Reports suggest that inositol is expected to grow at a CAGR of 6.8% in the next five years. It will reach 140 million USD in 20224 which was only 94 million USD in 2019. 

9. Inositol API Bulk Price

Inositol API is available in bulk from China. The average price of the inositol API is 3-40 USD per Kg. 

10. Inositol Manufacturers in China

Many manufactures of drugs are often looking for quality inositol at cheap and affordable prices. At pharmasources.com, you can easily find wholesale medical supplies supplier for this chemical from China, along with quotes, and reports on the quality of their products. 

Here are some of the leading producers of inositol API from China:

• Hebei Yuwei Biotechnology Co., Ltd
  

Hebei Yuwei Biotechnology Co., Ltd first started working in the year 2010. It provides materials like Inositol, TCP, DCP, Inositol hexaphosphate, Phytic acid, and Sodium phytate at wholesale rates. 

• DongtaihiryeBiotechnology Co., LTD
  

Dongtaihirye Biotechnology Company was established in 1999. It produces high-quality API materials like inositol, Inositol Hexanicotinate, and others. It is known for its high quality of materials all over China. 

• Nanjing Lifenergy R&D Co., Ltd.
  

Founded in 1999, the company is focused on manufacturing high-quality API materials used in areas like nephrology pharmaceuticals and others. 

• Tianjin Zhongrui Pharmaceutical Co., Ltd

Tianjin Zhongrui is known for its involvement in the production of raw pharmaceuticals, foods, and feed supplements. It is located in China and has been producing and supplying inositol API all over the world for years. 

11. FAQs

• How to cut coke with inositol?

Inositol is used to cut coke by adding it to coke in different concentrations. It is also used as a cutting agent for other drugs like methamphetamine, and heroin. The use is because of its texture, taste, and solubility. 

References:

1. https://pubchem.ncbi.nlm.nih.gov/compound/Inositol#section=CAS

2. https://go.drugbank.com/drugs/DB13178

3. https://en.wikipedia.org/wiki/Inositol

4. https://pubmed.ncbi.nlm.nih.gov/18074942/

5. https://pubmed.ncbi.nlm.nih.gov/2137771/

6. https://pubmed.ncbi.nlm.nih.gov/7793450/

7. https://pubmed.ncbi.nlm.nih.gov/17952759/

8. https://www.marketwatch.com/press-release/inositol-market-size-2021-research-report-by-opportunities-development-strategies-growth-rate-share-revenue-trends-and-forecast-to-2024-says-absolute-reports-2021-06-16

9. http://en.hbywswkj.com/a/guanyuwomen/

10. http://www.avbaike.cn/company-profile/dongtai-hirye-biotechnology-co-ltd-userId-16900.html

11. http://en.njsmn.com/

12. http://www.cphibiz.com/index.php?homepage=tjzr