Habitual use of glucosamine supplements is associated with a reduced risk for cardiovascular disease (CVD) events, according to a study published in The BMJ.

Hao Ma, M.D., Ph.D., from the School of Public Health and Tropical Medicine at Tulane University in New Orleans, and colleagues examined the correlation of habitual glucosamine use with the risk for CVD events in a prospective cohort study. Data were included for 466,039 participants who completed a questionnaire on supplement use. Participants were enrolled from 2006 to 2010 and followed to 2016.

The researchers noted 10,204 incident CVD events, 3,060 CVD deaths, 5,745 coronary heart disease events, and 3,263 stroke events during a median follow-up of seven years. Glucosamine use was associated with a significantly lower risk for total CVD events, CVD death, coronary heart disease, and stroke (hazard ratios, 0.85, 0.78, 0.82, and 0.91, respectively) after adjustment for age, sex, body mass index, race, lifestyle factors, dietary intakes, drug use, and other supplement use.

"We could not exclude the possibility that the observed inverse associations were driven by healthy lifestyle factors among glucosamine users, although we had carefully adjusted for potential confounding in our analyses," the authors write.

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