Hot-Melt Extrusion technique or named Melt Extrusion technique，It's a new preparation technology that the Europe, North America and Japan vigorously developed in recent years. The main function is to improve the solubility of the drug, the preparation of sustained release formulations……

?        Hot-Melt Extruder Basic parameters：

Capacity ：3kg/h，

Screw diameter (mm) ：15.6

Screw groove depth (mm) ：3.3

Maximum drive power（Kw) ：1.5

Maximum speed（rpm) ：600

Maximum output torque（N/m) ：33

Molding caliber（mm） ：2

Minimum sample weight（g） ：30

Residues（ml） ：20

Hot-melt extruder Technical advantages:

l Continuous production

l Excellent reproducibility

l No dust pollution

l Online control

?Hot-melt extruder Applications:

1. Adalat SL → Nifedipine    

 Accessories reinforcing material：PEG

2. Cris-PEG → Griseofulvin  

 Accessories reinforcing material：PEG

3. Kaletra   → Lopinavir / ritonavir

 Accessories reinforcing material：Copovidone

4. Rezulin   → Troglitazone

 Accessories reinforcing material：Povidone

Hot-melt extruder principle 

l  Hot-melt extruder technology ： Two or more of the samples were placed in a temperature controlled barrel，together heated to a molten state.Under the action of the screw, the samples were cut, mix, and finally through a die under a certain pressure，become dispersed uniformly shaped product

l  Hot-melt extruder basic idea：Place multiple segments threaded element within different functions in the axial space.So that multiple samples size decreases, and mutual penetration and exchange，eventually achieve molecular level mixing。