Letrozole is approved to be used alone or with other drugs to treat:
? Breast cancer in postmenopausal women who have any of the following types of breast cancer--
? Early-stage , hormone receptor–positive (HR+) breast cancer that has been treated.
? Early-stage breast cancer that has been treated with tamoxifen citrate for at least 5 years.
? Breast cancer that is locally advanced or has metastasized (spread to other parts of the body) and is HR+. It is used as the first treatment.
? Breast cancer that is locally advanced or has metastasized and it is not known whether the cancer is HR+ or hormone receptor negative (HR-). It is used as the first treatment.
? Breast cancer that has gotten worse after antiestrogen therapy. It is used as the second treatment.
Letrozole is also being studied in the treatment of other types of cancer.