What is ADC Linker?

ADC Linker refers to the linker in ADC (Antibody Drug Conjugate).

ADC is composed of Linker, Payload and monoclonal antibody (mAb). It combines the advantages of high specificity and targeted ability and strong killing effect, achieving precise and efficient killing of cancer cells, and has become a hot spot in the research and development of anti-cancer drugs. At present, there are mainly two types of ADC Linker in ADC drugs: the cleavable linker and the non-cleavable linker. The cleavable linker is designed to remain stable in the bloodstream and then release the Payload in the cells. Stable ADC drugs can ensure less Payload release before reaching tumor cells, thereby improving safety and limiting dosage. Fmoc-NH-(PEG)8-CH2CH2COOH is one of ADC linkers.

The advantages of Sinoway's ADC linker:

1) CDMO of Regulatory Starting Materials and Drug Intermediates (avoid the patent).
2) Products with high purity(etc. single impurity below 0.05%)
3) Green chemical technology platform used in Biological enzyme-catalyzed reaction, Continuous flow reaction, chiral synthesis, Commercial-scale ozonolysis, etc.
4) Production sites equipped with professional quality management under GMP guidance and EHS system, we can undertake high temperature and high pressure, low-temperature reactions, and other special reactions, with the qualification for the use of precursor and highly toxic products.
5) Most cost-saving proposals for our customers with competitive prices in the market. Some successful items we developed for our customers in our technology platform for your reference

Our main ADC linkers:

SMCC CAS No.: 64987-85-5

VAL-CIT-PAB CAS No.: 159857-79-1

Fmoc-NH-(PEG)8-CH2CH2COOH CAS No.: 756526-02-0

NH2-PEG2-C2-Boc CAS No.: 756525-95-8