Many chemical reactions, such as coupling reactions (Suzuki, Heck, Stille, Sonogashira, etc), ring closing metathesis (RCM), and hydrogenation, still require the use of metal catalysts, which can result in soluble metal contamination. In the case of active pharmaceutical ingredient (API) development, the metal catalyst must be removed to a regulated level. Purification of the API from remaining metal by traditional methods (chromatography, activated carbon, distillation, recrystallisation, ultrafiltration, or reverse osmosis) often leads to problems such as high costs, time consuming, low efficiency, and API losses. Chiral Chemistry has developed an efficient alternative: Silica Metal Scavengers. These scavengers are made with high purity silica gel which does not suffer from polymers' shortcomings, (e.g., limited choice of solvents, excessive swelling, extensive washings, poor selectivity, and static charge).